Scientific Validation
Digital Therapeutics
Peer reviewed publications
Rigorous scientific research is being conducted by external entities to validate the use of CogniFit for specific disorders, so that digital therapies can be offered in the future.
Below you can see the studies on specific disorders that have already been published in peer-reviewed scientific journals.
Cognitive Training Improves Sleep Quality and Cognitive Function among Older Adults with Insomnia
This study shows that lasting and personalized cognitive training is particularly indicated to generate combined cognitive and sleep enhancements in older adults with insomnia.
Haimov I, Shatil E (2013) Cognitive Training Improves Sleep Quality and Cognitive Function among Older Adults with Insomnia. PLOS ONE 8(4): e61390. doi:10.1371/journal.pone.0061390
Home-based personalized cognitive training in MS patients: a study of adherence and cognitive performance
The findings are evidence that cognitive training can significantly improve a wide range of skills in MS patients.
Shatil E, Metzer A, Horvitz O, Miller A. - Home-based personalized cognitive training in MS patients: A study of adherence and cognitive performance - NeuroRehabilitation 2010; 26:143-53.
Chronic Insomnia and Cognitive Functioning Among Older Adults
By using the CogniFit assessment of cognitive skills, this study implies that insomnia may have detrimental effects on some cognitive functions in healthy older adults.
Haimov I, Hanuka E, Horowitz Y. - Chronic insomnia and cognitive functioning among older adults - Behavioural sleep medicine 2008; 6:32-54.
Effect of Cognitive Remediation on Gait in Sedentary Seniors
Sedentary seniors with slow gait and falls improved mobility after cognitive training remediation using CogniFit personalized brain training program.
Verghese J, Mahoney J, Ambrose AF, Wang C, Holtzer R. - Effect of cognitive remediation on gait in sedentary seniors - J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1338-43.
Can the error detection mechanism benefit from training the working memory? A comparison between dyslexics and controls—an ERP study
When dyslexic college students trained with CogniFit personalized brain training program, their brain activity, memory and reading performance were shown to increase significantly, and results lasted up to six months after training on dyslexia.
Horowitz-Kraus T, Breznitz Z. - Can the error detection mechanism benefit from training the working memory? A comparison between dyslexics and controls- an ERP study -PLOS ONE 2009; 4:7141.
Personalized Cognitive Training in Unipolar and Bipolar Disorder: A Study of Cognitive Functioning
CogniFit personalized brain training program significantly reduced depression levels and improved Shifting, Divided Attention, and executive control score in patients with unipolar and bipolar disorder.
Preiss M, Shatil E, Cermáková R, Cimermanová D, Flesher I (2013) Personalized cognitive training in unipolar and bipolar disorder: a study of cognitive functioning. Frontiers in Human Neuroscience doi: 10.3389/fnhum.2013.00108.
Computer-Based Cognitive Training for Individuals With Intellectual and Developmental Disabilities: Pilot Study
This study shows highly encouraging results for individuals with Intellectual and Developmental Disabilities (IDD). First, participants using the CogniFit personalized brain training program presented a clear trend for cognitive improvement. Second, 100% of these participants completed the program.
James Siberski, Evelyn Shatil, Carol Siberski, Margie Eckroth-Bucher, Aubrey French, Sara Horton, Rachel F. Loefflad, and Phillip Rouse - Computer-Based Cognitive Training for Individuals With Intellectual and Developmental Disabilities: Pilot Study - The American Journal of Alzheimer's Disease & Other Dementias 2014; doi: 10.1177/1533317514539376
Differential Effect of Cognitive Training on Executive Functions and Reading Abilities in Children With ADHD and in Children With ADHD Comorbid With Reading Difficulties
CogniFit's personalized training program was able to improve reading speed and accuracy in adolescents with ADHD and reading problems, as well as strengthening processing speed, spatial perception, and memory.
Horowitz-Kraus, T. (2013). Differential Effect of Cognitive Training on Executive Functions and Reading Abilities in Children With ADHD and in Children With ADHD Comorbid With Reading Difficulties. Journal of Attention Disorders, 19(6), 515–526. https://doi.org/10.1177/1087054713502079
Computerized Cognitive Training for Older Adults at Higher Dementia Risk due to Diabetes: Findings From a Randomized Controlled Trial
CogniFit personalized training has been able to improve the general cognitive status, both memory and non-memory related, in older people at high risk of dementia due to diabetes.
Bahar-Fuchs, A., Barendse, M. E. A., Bloom, R., Ravona-Springer, R., Heymann, A., Dabush, H., Bar, L., Slater-Barkan, S., Rassovsky, Y., & Schnaider Beeri, M. (2019). Computerized Cognitive Training for Older Adults at Higher Dementia Risk due to Diabetes: Findings From a Randomized Controlled Trial. The Journals of Gerontology: Series A, 75(4), 747–754. https://doi.org/10.1093/gerona/glz073
Can Intervention Programs Influence How the Dyslexic Brain Processes Low-Level Visual Stimuli?
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Mayseless, N. (2011). Can Intervention Programs Influence How the Dyslexic Brain Processes Low-Level Visual Stimuli? Developmental Neuropsychology, 36(7), 949–954. https://doi.org/10.1080/87565641.2011.606421
Cognitive Functioning and Its Relationship with Self-Stigma in Men with HIV Who Have Sex with Men: The Mediating Role of Health-Related Quality of Life
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Ruiz-Robledillo, N., Clement-Carbonell, V., Ferrer-Cascales, R., Portilla-Tamarit, I., Alcocer-Bruno, C., & Gabaldón-Bravo, E. (2021). Cognitive Functioning and Its Relationship with Self-Stigma in Men with HIV Who Have Sex with Men: The Mediating Role of Health-Related Quality of Life. Psychology Research and Behavior Management, Volume 14, 2103–2114. https://doi.org/10.2147/prbm.s332494
A Taxonomy of Serious Games for Dementia
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McCallum S., Boletsis C. (2013) A Taxonomy of Serious Games for Dementia. In: Schouten B., Fedtke S., Bekker T., Schijven M., Gekker A. (eds) Games for Health. Springer Vieweg, Wiesbaden; doi: 10.1007/978-3-658-02897-8_17
A Game a Day Keeps Cognitive Decline Away? A Systematic Review and Meta‑Analysis of Commercially‑Available Brain Training Programs in Healthy and Cognitively Impaired Older Adults
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Nguyen, L., Murphy, K., & Andrews, G. (2021). A Game a Day Keeps Cognitive Decline Away? A Systematic Review and Meta-Analysis of Commercially-Available Brain Training Programs in Healthy and Cognitively Impaired Older Adults. Neuropsychology Review. https://doi.org/10.1007/s11065-021-09515-2
Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
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Marusic, U., Verghese, J., & Mahoney, J. R. (2022). Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation? Frontiers in Aging Neuroscience, 14.
The effect of co-dependent (thinking in motion [TIM]) versus single-modality (CogniFit) interventions on cognition and gait among community-dwelling older adults with cognitive impairment: a randomized controlled study
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Embon-Magal, S., Krasovsky, T., Doron, I., Asraf, K., Haimov, I., Gil, E., & Agmon, M. (2022). The effect of co-dependent (thinking in motion [TIM]) versus single-modality (CogniFit) interventions on cognition and gait among community-dwelling older adults with cognitive impairment: a randomized controlled study. BMC Geriatrics, 22(1)
Memory function performance in individuals classified as overweight, obese, and normal weight
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Berbegal M, Tomé M, Sánchez-SanSegundo M, Zaragoza-Martí A and Hurtado-Sánchez JA (2022) Memory function performance in individuals classified as overweight, obese, and normal weight. Front. Nutr. 9:932323. doi: 10.3389/fnut.2022.932323
Personalized Computerized Training for Cognitive Dysfunction after COVID-19: A Before-and-After Feasibility Pilot Study
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Duñabeitia, J.A.; Mera, F.; Baro, Ó.; Jadad-Garcia, T.; Jadad, A.R. (2023). Personalized Computerized Training for Cognitive Dysfunction after COVID-19: A Before-and-After Feasibility Pilot Study. Int. J. Environ. Res. Public Health, 20, 3100.
Digital Therapeutics for Insomnia: Assessing the Effectiveness of a Computerized Home-Based Cognitive Stimulation Program
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Tapia, J.L., Puertas, F.J., & Duñabeitia, J.A. (2023). Digital Therapeutics for Insomnia: Assessing the Effectiveness of a Computerized Home-Based Cognitive Stimulation Program. J. Integr. Neurosci. 22(2), 34
Effectiveness of a Computerized Home-Based Cognitive Stimulation Program for Treating Cancer-Related Cognitive Impairment
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Tapia, J. L., Taberner-Bonastre, M. T., Collado-Martínez, D., Pouptsis, A., Núñez-Abad, M., & Duñabeitia, J. A. (2023). Effectiveness of a Computerized Home-Based Cognitive Stimulation Program for Treating Cancer-Related Cognitive Impairment. International Journal of Environmental Research and Public Health, 20, 4953.
Randomized clinical trial of integral cognitive remediation program for major depression (INCREM)
Vicent-Gil, M., González-Simarro, S., Raventós, B., Vera, J. G., Martínez, E., Sabaté-Cao, C., Perez-Blanco, J., Puigdemont, D., De Diego-Adeliño, J., Alemany, C., Serra-Blasco, M., Cardoner, N., & Portella, M. J. (2022). Randomized clinical trial of integral cognitive remediation program for major depression (INCREM). Journal of Affective Disorders, 310, 189-197. https://doi.org/10.1016/j.jad.2022.05.016
Technologies for Cognitive Training and Cognitive Rehabilitation for People With Mild Cognitive Impairment and Dementia. A Systematic Review
Irazoki, E., Contreras-Somoza, L. M., Toribio-Guzmán, J. M., Río, C. J., Moll, H. A., & Franco, M. (2020). Technologies for Cognitive Training and Cognitive Rehabilitation for People With Mild Cognitive Impairment and Dementia. A Systematic Review. Frontiers in Psychology, 11. https://doi.org/10.3389/fpsyg.2020.00648
Does computerized cognitive training improve diabetes self-management and cognition? A randomized control trial of middle-aged and older veterans with type 2 diabetes
Silverman, J. M., Zhu, C. W., Schmeidler, J., Lee, P. G., Alexander, N. B., Guerrero-Berroa, E., Beeri, M. S., West, R. K., Sano, M., Nabozny, M., & Karran, M. (2022). Does computerized cognitive training improve diabetes self-management and cognition? A randomized control trial of middle-aged and older veterans with type 2 diabetes. Diabetes Research and Clinical Practice, 195, 110149. https://doi.org/10.1016/j.diabres.2022.110149
Tailored and Adaptive Computerized Cognitive Training in Older Adults at Risk for Dementia: A Randomized Controlled Trial
Bahar-Fuchs, A., Webb, S. L., Bartsch, L., Clare, L., Rebok, G. W., Cherbuin, N., & Anstey, K. J. (2017). Tailored and adaptive computerized cognitive training in older adults at risk for dementia: a randomized controlled trial. Journal of Alzheimer’s Disease, 60(3), 889-911. https://doi.org/10.3233/jad-170404
Enhancing Executive Functions in Pediatric Epilepsy: Feasibility and Efficacy of a Computerized Cognitive Training Program
Tapia, J. L., Aras, L. M., & Duñabeitia, J. A. (2024). Enhancing Executive Functions in Pediatric Epilepsy: Feasibility and Efficacy of a Computerized Cognitive Training Program. Children, 11(4), 484. https://doi.org/10.3390/children11040484
Enhancing social-communication and behavior skills in adolescents with intellectual disabilities through computerized cognitive training
Georgoula, E., & Koustriava, E. (2024). Enhancing social-communication and behavior skills in adolescents with intellectual disabilities through computerized cognitive training. International Journal of Instruction, 17(4), 421-440.
Neuropsychological rehabilitation on declarative memory and functionality in an adult with epilepsy and left temporal lobectomy
López-Hernández, K., Arias-Ramírez, Y. Z., Carvajal-Castrillón, J. S., & Pineda-Salazar, D. A. (2022). Rehabilitación neuropsicológica en memoria declarativa y la funcionalidad en un adulto con epilepsia y lobectomía temporal izquierda. Revista Ecuatoriana De Neurologia, 31(1), 33–39. https://doi.org/10.46997/revecuatneurol31100033
Impact of computerized neuropsychological rehabilitation in a patient with sickle cell disease and ADHD. Single case experimental study.
Pérez-Pereira, J. P., & Cuartas-Arias, M. (2023). Impacto de la rehabilitación neuropsicológica computarizada en un paciente con anemia de células falciformes y TDAH. Estudio experimental de caso único. Revista de investigación e innovación en ciencias de la salud, 5(1), press. https://doi.org/10.46634/riics.186
Intervention modalities for brain fog caused by long-COVID: systematic review of the literature
Gorenshtein, A., Liba, T., Leibovitch, L., Stern, S., & Stern, Y. (2024). Intervention modalities for brain fog caused by long‑COVID: systematic review of the literature. Neurological Sciences. https://doi.org/10.1007/s10072-024-07566-w
Towards a Choice of Correctional Computer Programs for Cognitive Rehabilitation of Cardiac Patients
Solodukhin, A. V., Yanitskii, M. S., & Seryi, A. V. (2020) Towards a Choice of Correctional Computer Programs for Cognitive Rehabilitation in Cardiac Patients. Russian Psychological Journal, Vol. 17, No. 1, 5–14. doi:10.21702/rpj.2020.1.1
Technologies for Cognitive Training and Cognitive Rehabilitation for People With Mild Cognitive Impairment and Dementia. A Systematic Review
Irazoki, E., Contreras-Somoza, L. M., Toribio-Guzmán, J. M., Río, C. J., Moll, H. A., & Franco, M. (2020). Technologies for Cognitive Training and Cognitive Rehabilitation for People With Mild Cognitive Impairment and Dementia. A Systematic Review. Frontiers in Psychology, 11. https://doi.org/10.3389/fpsyg.2020.00648
Technology‐enhanced cognitive training for individuals with autism spectrum disorder and intellectual disability
Georgoula, E., Koustriava, E., & Papadopoulos, K. (2025). Technology‐enhanced cognitive training for individuals with autism spectrum disorder and intellectual disability. British Journal of Special Education. https://doi.org/10.1111/1467-8578.70026
United States